abstract：BACKGROUND:To improve the early diagnosis of hepatocellular carcinoma (HCC), more effective diagnostic biomarkers are needed. A combination of biomarkers is reported to distinguish individuals with early-stage HCC from at-risk individuals. METHODS:Participants in this study were recruited from six hospitals in China. ...

journal_title：EBioMedicine

authors： Cheng K,Shi J,Liu Z,Jia Y,Qin Q,Zhang H,Wan S,Niu Z,Lu L,Sun J,Xue J,Lu C,Wei X,Guo L,Zhang F,Zhou D,Tang Y,Hu Y,Huang Y,Chen Y,Lau WY,Cheng S,Liu S

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Lipid accumulation has been highlighted in cancer development and progression, but the exact mechanism remains unclear in renal cell carcinoma (RCC). MicroRNAs (miRNAs) have been confirmed to participate in the pathological processes of cancers, including tumour occurrence and inhibition. However, the role a...

journal_title：EBioMedicine

authors： Xiao W,Wang C,Chen K,Wang T,Xing J,Zhang X,Wang X

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Genomically-guided clinical trials are performed across different tumor types sharing genetic mutations, but trial organization remains complex. Here we address the feasibility and utility of routine somatic and constitutional exome analysis in metastatic cancer patients. METHODS:Exoma trial (NCT02840604) i...

journal_title：EBioMedicine

authors： Réda M,Richard C,Bertaut A,Niogret J,Collot T,Fumet JD,Blanc J,Truntzer C,Desmoulins I,Ladoire S,Hennequin A,Favier L,Bengrine L,Vincent J,Hervieu A,Dusserre JG,Lepage C,Foucher P,Borg C,Albuisson J,Arnould L,Na

更新日期：2020-01-01 00:00:00

abstract：:The transcription factor Bach1 impairs angiogenesis after ischemic injury by suppressing Wnt/β-catenin signaling; however, the specific domains responsible for the anti-angiogenic effects of Bach1 remain unclear. This study determined the role of the BTB domain of Bach1 in ischemic angiogenesis. Bach1 is highly expres...

journal_title：EBioMedicine

authors： Jiang L,Jia M,Wei X,Guo J,Hao S,Mei A,Zhi X,Wang X,Li Q,Jin J,Zhang J,Li S,Meng D

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Half of muscle-invasive bladder cancer patients will relapse with metastatic disease and molecular tests to predict relapse are needed. TP63 has been proposed as a prognostic biomarker in bladder cancer, but reports associating it with clinical outcomes are conflicting. Since TP63 is expressed as multiple is...

journal_title：EBioMedicine

authors： Bankhead A 3rd,McMaster T,Wang Y,Boonstra PS,Palmbos PL

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Some interstitial lung disease (ILD) patients develop a progressive fibrosing-ILD phenotype (PF-ILD), with similar persistent lung function decline suggesting common molecular pathways involved. Nintedanib, a tyrosine kinase inhibitor targeting the PDGF, FGF, VEGF and M-CSF pathways, has shown comparable eff...

journal_title：EBioMedicine

authors： Hoffmann-Vold AM,Weigt SS,Saggar R,Palchevskiy V,Volkmann ER,Liang LL,Ross D,Ardehali A,Lynch JP 3rd,Belperio JA

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The infiltrative nature and lymphatic metastasis of head and neck squamous cell carcinoma (HNSCC) are the main reasons leading to its poor prognosis. METHODS:A multimodal surface-enhanced resonance Raman spectroscopy (SERRS) and magnetic resonance (MR) nanoprobe, in which paramagnetic chelators and heptamet...

journal_title：EBioMedicine

authors： Sun P,Zhang Y,Li K,Wang C,Zeng F,Zhu J,Wu Y,Tao X

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian cancer (EOC) with distinct pathological, biological, and molecular features. OCCCs are more resistant to conventional treatment regimen of EOC and have the worst stage-adjusted prognosis amongst EOC subtypes. As the OCCC inci...

journal_title：EBioMedicine

authors： Tan TZ,Ye J,Yee CV,Lim D,Ngoi NYL,Tan DSP,Huang RY

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Pediatric high-grade gliomas (pHGG) are the leading cause of cancer-related death during childhood. Due to their diffuse growth characteristics, chemoresistance and location behind the blood-brain barrier (BBB), the prognosis of pHGG has barely improved in the past decades. As such, there is a dire need for ...

journal_title：EBioMedicine

authors： Metselaar DS,Meel MH,Benedict B,Waranecki P,Koster J,Kaspers GJL,Hulleman E

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Recurrent implantation failure (RIF) remains a critical and challenging problem in assisted reproductive technology mainly due to impaired decidualization. The endocytic and transcytotic activity in the endometrium are crucial for decidualization. The most representative endocytic gene is the C-terminal Eps1...

journal_title：EBioMedicine

authors： Zhou Q,Yan G,Ding L,Liu J,Yu X,Kong S,Zhang M,Wang Z,Liu Y,Jiang Y,Kong N,Sun J,Sun H

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:HIV drug resistance (HIVDR) testing can assist clinicians in selecting treatments. However, high complexity and cost of genotyping assays limit routine testing in settings where HIVDR prevalence has reached high levels. METHODS:The oligonucleotide ligation assay (OLA)-Simple kit was developed for detection ...

journal_title：EBioMedicine

authors： Panpradist N,Beck IA,Vrana J,Higa N,McIntyre D,Ruth PS,So I,Kline EC,Kanthula R,Wong-On-Wing A,Lim J,Ko D,Milne R,Rossouw T,Feucht UD,Chung M,Jourdain G,Ngo-Giang-Huong N,Laomanit L,Soria J,Lai J,Klavins ED,Fr

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:BM32, a grass pollen allergy vaccine containing four recombinant fusion proteins consisting of hepatitis B-derived PreS and hypoallergenic peptides from the major timothy grass pollen allergens adsorbed on aluminium hydroxide has been shown to be safe and to improve clinical symptoms of grass pollen allergy ...

journal_title：EBioMedicine

authors： Eckl-Dorna J,Weber M,Stanek V,Linhart B,Ristl R,Waltl EE,Villazala-Merino S,Hummel A,Focke-Tejkl M,Froeschel R,Neubauer A,Henning R,Perkmann T,Valenta R,Niederberger V

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:KRAS mutations are the most frequent oncogenic aberration in lung adenocarcinoma. KRAS mutant isoforms differentially shape tumour biology and influence drug responses. This heterogeneity challenges the development of effective therapies for patients with KRAS-driven non-small cell lung cancer (NSCLC). METH...

journal_title：EBioMedicine

authors： Wang H,Lv Q,Xu Y,Cai Z,Zheng J,Cheng X,Dai Y,Jänne PA,Ambrogio C,Köhler J

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Active immunotherapy is an effective, long-lasting, cheap, and safe approach to suppress cancer progression; however, the key issue is to develop appropriate tumour vaccines. Oncoproteins are up-regulated under various stress conditions and promote cell survival. Oncoproteins and their immunogenic domains co...

journal_title：EBioMedicine

authors： Lin W,Liu J,Chen J,Li J,Qiu S,Ma J,Lin X,Zhang L,Wu J

更新日期：2019-11-01 00:00:00

abstract：:Pyrazinamide remains the only drug in the tuberculosis pharmacopeia to drastically shorten first-line therapy from nine to six months. Due to its unparalleled ability to sterilize non-replicating bacilli and reduce relapse rates, PZA is expected to be irreplaceable in future therapies against tuberculosis. While the m...

journal_title：EBioMedicine

authors： Lamont EA,Baughn AD

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Diabetic retinopathy, a vascular complication of diabetes mellitus, is the leading cause of visual impairment and blindness. circRNAs act as competing endogenous RNA, sponging target miRNA and thus influencing mRNA expression in vascular diseases. We investigated whether and how circDNMT3B is involved in ret...

journal_title：EBioMedicine

authors： Zhu K,Hu X,Chen H,Li F,Yin N,Liu AL,Shan K,Qin YW,Huang X,Chang Q,Xu GZ,Wang Z

更新日期：2019-11-01 00:00:00

abstract：:As our population grows older, age-related pathologies are becoming more prevalent. Deterioration of skeletal muscle and the immune system manifests as sarcopenia and immune senescence respectively. The disease burden of these pathologies emphasizes the need for a better understanding of the underlying mechanisms. Ske...

journal_title：EBioMedicine

authors： Nelke C,Dziewas R,Minnerup J,Meuth SG,Ruck T

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Chronic Hepatitis B (CHB) remains a major problem for global public health. Viral persistence and immune defects are the two major reasons for CHB, and it was hypothesized that based on a transient clearance of serum viral DNA and HBsAg "window stage", active immunization against hepatitis B virus (HBV) migh...

journal_title：EBioMedicine

authors： Shi B,Wu Y,Wang C,Li X,Yu F,Wang B,Yang Z,Li J,Liang M,Wen Y,Ying T,Yuan Z

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Accumulating evidence points to a close relationship between gut dysbiosis and colorectal cancer (CRC). As >90% of CRC develop from adenoma, we aimed to investigate the crucial role of imbalanced gut microbiota on the progression of intestinal adenoma. METHODS:The Apcmin/+ mice gavage with phosphate-buffere...

journal_title：EBioMedicine

authors： Li L,Li X,Zhong W,Yang M,Xu M,Sun Y,Ma J,Liu T,Song X,Dong W,Liu X,Chen Y,Liu Y,Abla Z,Liu W,Wang B,Jiang K,Cao H

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Urea, the end product of protein metabolism, has been considered to have negligible toxicity for a long time. Our previous study showed a depression phenotype in urea transporter (UT) B knockout mice, which suggests that abnormal urea metabolism may cause depression. The purpose of this study was to determin...

journal_title：EBioMedicine

authors： Wang H,Huang B,Wang W,Li J,Chen Y,Flynn T,Zhao M,Zhou Z,Lin X,Zhang Y,Xu M,Li K,Tian K,Yuan D,Zhou P,Hu L,Zhong D,Zhu S,Li J,Chen D,Wang K,Liang J,He Q,Sun J,Shi J,Yan L,Sands JM,Xie Z,Lian X,Xu

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Tissue stem cells (SCs) and cancer cells proliferation is regulated by many common signalling mechanisms. These mechanisms temporally balance proliferation and differentiation events during normal tissue homeostasis and repair. However, the effect of these aberrant signalling mechanisms on the ultimate fate ...

journal_title：EBioMedicine

authors： Chovatiya GL,Sunkara RR,Roy S,Godbole SR,Waghmare SK

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Metastasis is a major obstacle in the treatment of bladder cancer (BC). Circular RNAs exert various functions in the aggressive biological behaviour of cancers. In this study, we aimed to elucidate how circPICALM influences BC metastasis. METHODS:The expression of circPICALM was analysed by real-time PCR. T...

journal_title：EBioMedicine

authors： Yan D,Dong W,He Q,Yang M,Huang L,Kong J,Qin H,Lin T,Huang J

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Both idiopathic and familial Parkinson's disease are associated with mitochondrial dysfunction. Mitochondria have their own mitochondrial DNA (mtDNA) and previous studies have reported that the release of mtDNA is a biomarker of Parkinson's disease. METHODS:We have now investigated the relationship between ...

journal_title：EBioMedicine

authors： Podlesniy P,Puigròs M,Serra N,Fernández-Santiago R,Ezquerra M,Tolosa E,Trullas R

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Spleen tyrosine kinase (SYK) is frequently upregulated in recurrent ovarian carcinomas, for which effective therapy is urgently needed. SYK phosphorylates several substrates, but their translational implications remain unclear. Here, we show that SYK interacts with EGFR and ERBB2, and directly enhances their...

journal_title：EBioMedicine

authors： Yu Y,Suryo Rahmanto Y,Shen YA,Ardighieri L,Davidson B,Gaillard S,Ayhan A,Shi X,Xuan J,Wang TL,Shih IM

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The development of an effective vaccine preventing HIV-1 infection is hindered by the enormous antigenic variability and unique biochemical and immunological properties of HIV-1 Env glycoprotein, the most promising target for HIV-1 neutralizing antibody. Functional studies of rare elite neutralizers led to t...

journal_title：EBioMedicine

authors： Kosztyu P,Kuchar M,Cerny J,Barkocziova L,Maly M,Petrokova H,Czernekova L,Liskova V,Raskova Kafkova L,Knotigova P,Masek J,Turanek J,Maly P,Raska M

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Cisplatin resistance remains a major clinical obstacle to the successful treatment of non-small cell lung cancer (NSCLC). Scribble contributes to ROS-induced inflammation and cisplatin-elevated toxic reactive oxygen species (ROS) promotes cell death. However, it is unknown whether and how Scribble is involve...

journal_title：EBioMedicine

authors： Wang N,Song L,Xu Y,Zhang L,Wu Y,Guo J,Ji W,Li L,Zhao J,Zhang X,Zhan L

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Metastatic bladder cancer (BLCA) is a lethal disease with an unmet need for study. Transgelin (TAGLN) is an actin-binding protein that affects the dynamics of the actin cytoskeleton indicating its robust potential as a metastasis initiator. Here, we sought to explore the expression pattern of TAGLN and eluci...

journal_title：EBioMedicine

authors： Chen Z,He S,Zhan Y,He A,Fang D,Gong Y,Li X,Zhou L

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-like weak inducer of apoptosis (Tnfsf12; TWEAK) and its receptor Fibroblast growth factor-inducible 14 (Tnfrsf12a; Fn14) participate in the inflammatory response associated with vascular remodeling. However, the functional effect of TWEAK on vascular smooth muscle cells (VSMCs) is not c...

journal_title：EBioMedicine

authors： Méndez-Barbero N,Gutierrez-Muñoz C,Madrigal-Matute J,Mínguez P,Egido J,Michel JB,Martín-Ventura JL,Esteban V,Blanco-Colio LM

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:The identification of new biomarkers and the development of novel, targetable contexts of vulnerability are of urgent clinical need in drug-resistant metastatic colorectal cancer (mCRC). Aryl-Hydrocarbon-Receptor-Nuclear-Translocator-Like (ARNTL/BMAL1) is a circadian clock-regulated transcription factor prom...

journal_title：EBioMedicine

authors： Burgermeister E,Battaglin F,Eladly F,Wu W,Herweck F,Schulte N,Betge J,Härtel N,Kather JN,Weis CA,Gaiser T,Marx A,Weiss C,Hofheinz R,Miller IS,Loupakis F,Lenz HJ,Byrne AT,Ebert MP

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterized by emphysema and/or obstructive bronchiolitis. Deficiency in vitamin D3 (VD3), which regulates gene expression through binding to vitamin D receptor (VDR), is associated with high risks of COPD susceptibility. Alveolar macrophages (AM), which are ...

journal_title：EBioMedicine

authors： Hu G,Dong T,Wang S,Jing H,Chen J

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Sphingomyelin synthase 1 (SMS1) has been reported to participate in hepatitis and atherosclerosis. However, its role in autoimmune response is not clear. This study investigates the possible involvement of SMS1 in B-cell activation and lupus-like autoimmunity. METHODS:SMS1 knockout lupus-like animal model a...

journal_title：EBioMedicine

authors： Wang C,Ming B,Wu X,Wu T,Cai S,Hu P,Tang J,Tan Z,Liu C,Zhong J,Zheng F,Dong L

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Our previous study revealed that PLAGL2 or POFUT1 can promote tumorigenesis and maintain significant positive correlations in colorectal cancer (CRC). However, the mechanism leading to the co-expression and the underlying functional and biological implications remain unclear. METHODS:Clinical tumor tissues ...

journal_title：EBioMedicine

authors： Li D,Lin C,Li N,Du Y,Yang C,Bai Y,Feng Z,Su C,Wu R,Song S,Yan P,Chen M,Jain A,Huang L,Zhang Y,Li X

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Non-small cell lung carcinomas (NSCLC) are prevalent, lethal cancers with especially grim prospects due to late-stage detection and chemoresistance. Circular RNAs (circRNAs) are non-coding RNAs that participate in tumor development. However, the role of circRNAs in NSCLC is not well known. This study investi...

journal_title：EBioMedicine

authors： Wei S,Zheng Y,Jiang Y,Li X,Geng J,Shen Y,Li Q,Wang X,Zhao C,Chen Y,Qian Z,Zhou J,Li W

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Undernutrition is a serious global problem that contributes to increased child morbidity and mortality, impaired neurocognitive development, and decreased educational and economic attainment. Current interventions are only marginally effective, and identification of associated metabolic pathways can offer ne...

journal_title：EBioMedicine

authors： Moreau GB,Ramakrishnan G,Cook HL,Fox TE,Nayak U,Ma JZ,Colgate ER,Kirkpatrick BD,Haque R,Petri WA Jr

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Recurrent mutations in the promoter of the telomerase reverse transcriptase (TERT) gene (C228T and C250T) detected in tumours and cells shed into urine of urothelial cancer (UC) patients are putative biomarkers for UC detection and monitoring. However, the possibility of detecting these mutations in cell-fre...

journal_title：EBioMedicine

authors： Avogbe PH,Manel A,Vian E,Durand G,Forey N,Voegele C,Zvereva M,Hosen MI,Meziani S,De Tilly B,Polo G,Lole O,Francois P,Delhomme TM,Carreira C,Monteiro-Reis S,Henrique R,Abedi-Ardekani B,Byrnes G,Foll M,Weiderpass E

更新日期：2019-06-01 00:00:00

abstract：:Metabolites have emerged as the quintessential effectors mediating the impact of the commensal microbiome on human physiology, both locally at the sites of microbial colonization and systemically. The endocrine activity of the microbiome and its involvement in a multitude of complex diseases has made microbiome-modula...

journal_title：EBioMedicine

authors： Descamps HC,Herrmann B,Wiredu D,Thaiss CA

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Abdominal fat mass is associated with metabolic risk whilst gluteal femoral fat is paradoxically protective. MicroRNAs are known to be necessary for adipose tissue formation and function but their role in regulating human fat distribution remains largely unexplored. METHODS:An initial microarray screen of a...

journal_title：EBioMedicine

authors： Hilton C,Neville MJ,Wittemans LBL,Todorcevic M,Pinnick KE,Pulit SL,Luan J,Kulyté A,Dahlman I,Wareham NJ,Lotta LA,Arner P,Lindgren CM,Langenberg C,Karpe F

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Corneal neovascularization (angiogenesis and lymphangiogenesis) compromises corneal transparency and transplant survival, however, the molecular mechanisms of corneal host epithelial and stromal cells in neovascularization have not yet been fully elucidated. Furthermore, the contribution and mechanism of cor...

journal_title：EBioMedicine

authors： Yu H,Sun L,Cui J,Li Y,Yan Y,Wei X,Wang C,Song F,Jiang W,Liu Y,Ge H,Qian H,Li X,Tang X,Liu P

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Gastric cancer (GC) ranks the fifth most common cancer, and chemotherapy is one of the most common treatments for GC. However, chemoresistance limits the effectiveness of chemotherapy and leads to treatment failure. This study aims to investigate the biological effect of miR-567 on gastric tumourigenesis and...

journal_title：EBioMedicine

authors： Zhang F,Li K,Yao X,Wang H,Li W,Wu J,Li M,Zhou R,Xu L,Zhao L

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Clinical trials on multiple sclerosis with repeated injections of monoclonal antibodies depleting CD4+ T cells have not resulted in much success as a disease therapy. Here, we developed an immunotherapy for EAE in mice by combining a transient depletion of T cells together with the administration of neuron d...

journal_title：EBioMedicine

authors： Kasagi S,Wang D,Zhang P,Zanvit P,Chen H,Zhang D,Li J,Che L,Maruyama T,Nakatsukasa H,Wu R,Jin W,Sun L,Chen W

更新日期：2019-06-01 00:00:00